Bone Abstracts

Objectives: Weight loss therapy is the principal non-pharmacological method for prevention and treatment of simple obesity in childhood. This intervention may influence bone metabolism in children, but this phenomenon is not well understood. The aim of this study was to assess the changes in body composition and in the profile of bone markers after weight loss in obese prepubertal children.Methods: We determined serum BALP (bone alkaline phosphatase), CT...

Introduction: Osteocalcin (OC) is the noncollagenous protein of bone matrix produced by osteoblasts which play an important role in bone metabolism. In its carboxylated form (c-OC) osteocalcin binds to hydroxyapatite in bone and plays a regulatory role in bone formation and mineralization. In contrast, undercarboxylated OC (uc-OC) binds less effectively to hydroxyapatite and a significant association has been found between fracture incidence and uc-OC in elderly subjects. Unde...

Introduction: Obesity is the direct cause of a number of immediate problems during childhood. Among them the high prevalence of fractures and joint problems in obese children was observed. Leptin may influence the development and bone remodeling in children, but this phenomenon is not well understood. Therefore, we studied the relationships between leptin and bone turnover markers, growth factors and anthropometric parameters in obese children.Descriptio...

Objectives: As the receptor activator of the nuclear factor κB (RANK)/receptor activator of the nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) cytokine system is essential for osteoclastogenesis and Wnt signaling pathway for osteoblastogenesis, we decided to assess these two main bone regulatory pathways in patients with malignant bone tumors on the completion of anticancer therapy.Methods: The study included 35 patients (median age 15....